Hemoglobin D in a Patient with Sickle Cell Disease (Genotype HbSS)

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sickle cell hemoglobin d disease first reported case in iran

a case of sickle cell hb d disease is reported in  young iranian male. the father of whom carried an as sickle cell trait and the mother an ad trait. this disease was diagnosed by hb electrophoresis. agar gel electrophoresis sickling and solubility tests.this is the first case of sickle cell hb d disease reported in iran.

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Human hemoglobins (Hbs) are known to be immunogenic, and both normal and variant forms of Hb have been shown to stimulate antibody formation in a variety of animal species. In patients who are homozygous for the sickle Hb (HbS) mutation, transfusion of normal, HbA-containing erythrocytes provides a potential stimulus for HbA alloimmunization. We tested serum samples for the presence of anti-Hb ...

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ژورنال

عنوان ژورنال: The Journal of Applied Laboratory Medicine

سال: 2018

ISSN: 2475-7241

DOI: 10.1373/jalm.2017.025452